Two pathways
GHRH analogs like CJC-1295 and sermorelin act on the GHRH receptor. Ghrelin mimetics like Ipamorelin, GHRP-2 and GHRP-6 act on the GHS receptor.
DAC vs. no DAC
'DAC' (Drug Affinity Complex) extends half-life. The no-DAC version, also called Mod GRF 1-29, is shorter-acting.
Where tesamorelin fits
Tesamorelin is another GHRH analog, and is the active ingredient in an FDA-approved prescription product. Research vials are not that product.
Frequently asked questions
- Is Ipamorelin selective?
- Ipamorelin is described in the literature as a selective GHS-R agonist with less effect on cortisol and prolactin than older GHRPs in animal studies.